If you really love comic books and want to start your own comic book business there are many ways you can go about this. If you want to have a real location where customers can come in and browse, you have to start looking for a suitable place to set up your business. You need to have the business in a location where you get exposure to lots of people, so a logical place would be in a mall or shopping center. However, the overhead would be high for rental space and you have to figure out whether you are going to work in the store or hire an employee or two. Added to the cost is the setting up of the stands and the supply of comics from the publishers. It is possible to work out a consignment deal with some publishers where you don't have to pay for the comics up front and you can return the ones that don't sell.
You can set up an online comic book business that will not require an initial outlay of capital and very little of your own time. When you take this route, you have to buy a domain name and get web hosting service. Then you can list the titles of the comic books you have for sale and the prices. Searchers coming to your site can place their orders directly online and all you have to do is process the orders. Even with this type of business. You don't necessarily have to have an inventory of comic books, because once you receive an order, you can them place the order to go to the customer directly from the publisher.
If you sell used comic books, you will have to have an inventory to get started in your own comic book business. You need a copy of a reputable guide that gives the prices of the comics, so you know how much to pay and how much to charge. One thing you should know is that if people come to you to sell comics that do have some value, you never give them the actual retail value, because this is the way you make your profits. No one will pay more than the price listed in the guides, so if you do business in this way you won't make a lot of money.